Conventional Antibody

Conventional Antibody

  • Intact antibodies (immunoglobulins IgG, IgM, IgA, and IgE) are highly specific targeting reagents that form part of our key defense against pathogens and toxins.

  • IgG, the main serum antibody, the intact form of which is almost exclusively used in therapeutic antibodies, is a Y-shaped, multidomain protein with antigen-binding sites located on the two Fab (antigen-binding fragment) tips and effector functions mediated by the stem Fc (crystallizable fragment) domain (see Figure).

  • There is a range of applications for which the Fc-mediated effects are neither required nor are desirable.

  • Inappropriate activation of the Fc receptor-expressing cells by antibodies can lead to cytokine release and toxicity.