Advantages of Single Domain Antibody

Advantages of Single Domain Antibody

  • High stability to function and exist within extreme conditions (high temperatures and pH).

  • Can recognize novel epitopes that are normally not recognized by conventional antibodies.

  • Their small molecular size helps with rapid tissue penetration and labeling applications, including crossing the blood-brain barrier.

  • Improved bioavailability for pharmaceutical applications.

  • Cheaper alternative for large-scale production.

  • Increased potential in downstream antibody engineering (bi-specific antibody, humanization).

  • Can be expressed in both eukaryotic and prokaryotic systems.

    Engineered sdAb

    Singh Biotechnology using our proprietary technology have successfully bio-engineered multiple sdAb to specifically target and inhibit :

  • STAT3 (Signal Transducer and Activator of Transcription 3)

  • KRAS (Kirsten Rat Sarcoma)

  • TNF-α (Tumor Necrosis Factor Alpha)